As the 2025 NFL season kicks off, bettors are focusing on promising quarterback player props for Week 1. Two quarterbacks, Jared Goff of the Detroit Lions and Kyler Murray of the Arizona Cardinals, are drawing attention for their favorable matchups against the Green Bay Packers and New Orleans Saints, respectively. Both players have the potential to exploit weaknesses in the opposing defenses, making them worthwhile targets for prop bets.

Jared Goff’s Opportunities Against Green Bay

Goff’s matchup against the Packers looks promising. The Lions’ offense is set to capitalize on Green Bay’s zone-heavy defensive scheme. Goff is projected to exceed 243.5 passing yards at odds of -120. Historically, he has performed well against zone defenses, ranking as the second-most efficient passer in the NFL last season in such scenarios.

The Lions recently hired John Morton as their offensive coordinator, a move that could enhance Goff’s production. Morton previously guided the Denver Broncos to a respectable offensive performance, finishing 13th in deep pass percentage and sixth in deep PFF passing grade. This shift in offensive strategy could benefit Goff, allowing him to showcase his abilities while supported by a strong cast of playmakers.

The Lions enter this game with advantages at every position. Goff’s familiarity with the offensive system and the talent surrounding him suggests that he is well-equipped to take advantage of the Packers’ defensive weaknesses.

Kyler Murray’s Ground Game Against New Orleans

Murray’s matchup against the Saints presents another opportunity for bettors. The line for his rushing yards is set at 21.5, also with odds of -120. Given his athleticism, this figure appears low, especially considering that Murray averaged 7.3 yards per carry last season, ranking him second among starting quarterbacks.

Last season, the Saints struggled to contain mobile quarterbacks, allowing the most rushing yardage on scrambles, totaling 389 yards. In fact, they permitted the eighth-most rushing yards to quarterbacks throughout the season, with more than 50 yards conceded in three of their last five games. This trend highlights the potential for Murray to exploit gaps in New Orleans’ defense, especially when he breaks the pocket.

Bettors are encouraged to consider these quarterback props as they prepare for the opening week of the NFL season. With favorable matchups and historical data supporting their performances, Goff and Murray could deliver significant returns for those willing to place their bets.

As the NFL continues to evolve, tools like the PFF Player Props Tool provide valuable insights and data, helping both seasoned bettors and newcomers make informed decisions. As the excitement builds for Week 1, these quarterback props stand out as compelling options to watch.